Nicotine sensitized DDT formulations.

Effects of mGluII Receptor Antagonist LY341495 on Nicotine-Sensitized Rats

Iptakalim Preferentially Decreases Nicotine-induced Hyperlocomotion in Phencyclidine-sensitized Rats: A Potential Dual Action against Nicotine Addiction and Psychosis

OBJECTIVE Iptakalim is a putative ATP-sensitive potassium (K(ATP)) channel opener. It is also a novel nicotinic acetylcholine receptor (nAChR) blocker and can antagonize nicotine-induced increase in dopamine release in the nucleus accumbens. Our recent work also shows that iptakalim exhibits a clozapine-like atypical antipsychotic profile, indicating that iptakalim may possess a dual action aga...

DDT Paradox

Hwang B-F, Lee YL, Jaakkola JJ. 2011. Air pollution and stillbirth: a population-based case–control study in Taiwan. Environ Health Perspect 119:1345–1349; http://dx.doi. org/10.1289/ehp.1003056 [Online 29 March 2011]. Strand L, Barnett A, Tong S. 2011. Methodological challenges when estimating the effects of season and seasonal exposures on birth outcomes. BMC Medical Research Methodology 11 (...

Composite HPMC and sodium alginate based buccal formulations for nicotine replacement therapy.

Smoking cessation is of current topical interest due to the significant negative health and economic impact in many countries. This study aimed to develop buccal films and wafers comprising HPMC and sodium alginate (SA) for potential use in nicotine replacement therapy via the buccal mucosa, as a cheap but effective alternative to currently used nicotine patch and chewing gum. The formulations ...

DDT December 2005.qxp

1697 www.drugdiscoverytoday.com Although early detection of pathology can greatly improve patient outcomes, there are relatively few good noninvasive molecular tools for diagnosis of early-stage disease, such as premalignant cancer [1,2], or for prognosis, such as identifying cardiac patients at higher risk of dying (e.g. the Framingham Heart Study), or of non-responsiveness to therapy [3]. The...